Real R.O.U.S.’s
By Laura Myers
GRASSY KEY, Florida (Reuters) - Deep in the heart of the Florida Keys, wildlife officials are laying bait laced with poison to try to wipe out a colony of enormous African rats that could threaten crops and other animals.
U.S. federal and state officials are beginning the final phase of a two-year project to eradicate the Gambian pouched rats, which can grow to the size of a cat and began reproducing in the remote area about eight years ago.
“This is the only place in the United States where this is occurring,” said Gary Witmer, a biologist with the U.S. Department of Agriculture’s National Wildlife Research Center in Fort Collins, Colorado.

Pretty sure this qualifies as a R.O.U.S.
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Comments
Oh Nate, you and your technology! Those rats were actually people in rats costumes!
From IMDB.com:
The giant rodents were created with diminutive actors inside rat suits. On the day Westley was supposed to battle the giant rat, the “rat actor” was pulled over for speeding and subsequently arrested, and actually had to be bailed out of jail by the filmmakers so the scene could be filmed.
I maintain that those actors were anamatronic cyborgs sent to that soundstage to kill Carey Elwes. Fortunately, they did not succeed.
I’m pretty sure that the Rodents of Unusual Size were a bit bigger and moved about in a more anamatronic and herky-jerky manner.